Model Answer

Introduction

India has established itself as a global leader in the pharmaceutical industry, ranking 3rd in the world for pharmaceutical product production by volume and 14th by value (Economic Survey 2022-23). Technology has played a pivotal role in reshaping both drug development and manufacturing processes, enhancing efficiency, and positioning India at the forefront of pharmaceutical innovation.

1. Drug Development

Artificial Intelligence (AI) and Machine Learning (ML): AI and ML are accelerating drug discovery by enabling rapid analysis of large datasets, thereby identifying potential drug candidates quickly. For instance, the Indian start-up Peptris Technologies leverages AI/ML-based computational platforms to speed up the process of finding novel drugs.
Gene Editing: Techniques like CRISPR are being employed for gene therapies, enabling precise genetic modifications. Intas Pharmaceuticals uses this technology to develop treatments for genetic disorders.
Personalized Medicine: Bioinformatics and genomic sequencing technologies allow for the tailoring of treatments to individuals’ genetic profiles. MedGenome offers genomic testing services, helping oncologists design personalized cancer treatment plans.

2. Drug Manufacturing

Blockchain: Blockchain technology enhances supply chain transparency by recording details such as drug origin, manufacturing, and expiry dates. MedSecure uses a blockchain-based system to track drugs from manufacturing to consumers.
Internet of Things (IoT): IoT has revolutionized drug manufacturing by providing real-time data through connected devices and sensors. This ensures better monitoring, control, and consistency in production.
Robotic Process Automation (RPA): The use of robots for tasks like dispensing, labeling, and packaging has minimized human error and increased efficiency.
3D Printing: This technology enables the production of complex drug structures and personalized drug formulations, significantly improving patient outcomes.

Conclusion

Technology in India’s pharmaceutical industry is streamlining drug development and manufacturing processes, enhancing the speed of innovation, improving product quality, and ensuring a more personalized approach to medicine.

Model Answer

Smart materials are advanced substances that react to external stimuli, such as stress, temperature, light, or magnetic fields, by altering their properties in a controlled manner. These materials find applications across energy, healthcare, and environmental sustainability due to their responsiveness and adaptability.

Potential in Addressing Global Challenges

1. Energy Efficiency

• Energy Harvesting: Piezoelectric materials convert ambient mechanical energy into electricity, such as generating power from foot traffic in high-traffic zones.
• Energy Consumption Reduction: Thermochromic windows regulate transparency based on temperature, optimizing heating and cooling costs in buildings.
• Construction Efficiency: Self-compacting concrete eliminates the need for mechanical vibration during construction, reducing labor costs and environmental impact.

2. Healthcare

• Targeted Drug Delivery: Smart polymers can deliver medication directly to specific sites, such as tumors, increasing treatment effectiveness and minimizing side effects.
• Innovative Medical Devices: Shape-memory alloys are utilized in stents and implants that adapt at body temperature to support cardiovascular surgeries.

3. Environmental Sustainability

• Recyclability: Materials like graphene allow reprocessing and repurposing, extending their lifecycle and reducing waste.
• Pollution Control: Electrochromic materials in smart windows adjust opacity, reducing urban light pollution.
• Water Treatment: Bioinspired membranes selectively filter contaminants, enhancing water purification and reuse.

Conclusion

Smart materials are transformative, addressing global challenges in energy, healthcare, and environmental sustainability. Their applications align with Sustainable Development Goals (SDGs 7, 9, 11, and 13), contributing to a sustainable and resilient future.

Model Answer

The Advanced Nuclear Energy for Enriched Life (ANEEL) is an innovative nuclear fuel technology that combines Thorium and High Assay Low Enriched Uranium (HALEU). HALEU refers to uranium enriched such that the concentration of the fissile isotope uranium-235 (U-235) ranges between 5% and 20%, making it more efficient for nuclear reactors. This technology has significant implications for the future of clean energy and nuclear power.

Main Advantages of ANEEL Technology

1. Compatibility with Existing Infrastructure
   ANEEL can be seamlessly integrated with existing Pressurized Heavy-Water Reactors (PHWRs), a core part of India’s nuclear power infrastructure. This compatibility ensures that the technology can be adopted without requiring new reactor designs, simplifying its implementation.
2. Reduction in Import Dependency
   India has vast reserves of Thorium, and ANEEL utilizes this resource along with HALEU. This reduces India’s dependence on imported uranium, which has been a major concern for energy security. India’s Thorium reserves are the largest in the world, and utilizing them will enhance national energy independence.
3. Higher Fuel Efficiency
   ANEEL offers significantly higher fuel efficiency. For example, ANEEL fuel can achieve a burn-up rate of 60,000 MW-days per tonne, compared to only 7,000 MW-days per tonne for conventional uranium fuel in PHWRs. This means that ANEEL fuel lasts longer and produces more energy from the same amount of material.
4. Cost Savings
   Due to the longer life cycle of ANEEL fuel and fewer bundles needed for replacement, the technology leads to substantial cost savings in terms of fuel transportation and disposal of spent fuel. A PHWR using ANEEL requires only one bundle replacement daily, compared to eight with traditional uranium.
5. Reduced Nuclear Waste
   The higher burn-up rate of ANEEL results in a significant reduction in nuclear waste, with a reduction of over 80% in waste generation. This makes ANEEL a more environmentally friendly option compared to conventional nuclear fuels.
6. Contribution to Clean Energy
   As a zero-carbon fuel, ANEEL supports India’s target of achieving net-zero emissions by 2070. India’s Thorium reserves alone could sustain this technology for over a century, providing a long-term, sustainable solution for clean energy generation.
7. Enhanced Nuclear Security
   ANEEL fuel is incompatible with nuclear weapons production, making it a safer choice from a proliferation standpoint. This adds to nuclear security and enhances confidence among international uranium suppliers.

In conclusion, ANEEL technology offers economic, environmental, and security benefits, positioning it as a promising solution for clean, sustainable, and energy-secure nuclear power.