Music is made from a combination of different sounds. Sound is made up of vibration which propagates in a medium in the form of a wave. The frequency of sound wave between 20 to 20,000 Hz is classified under audible range.. If the sound wave is moving through plant cells, the vibration would transfer its energy to the particles/molecules in cells and cause its displacement, which can be a reason of the biological effect of the sound vibration.Every organism is exposed to a range of natural sound frequencies and intensities but only a short range is perceived by them. Exposing plants to artificial sound might interfere with the natural frequencies affecting optimal communication within and among different species of the niche, producing adverse effects. A higher intensity sound might supress the perception of lower intensity sound and might interfere with perception of natural sounds such as bee buzz for pollination, insect chewing for eliciting defense response, flowing water for orienting roots.Studies have shown frequency specific responses in different species. Thus, one of the key challenges is to identify specific sound wave treatment for individual plant species for desired outcome such as enhanced yield, biomass, quality, tolerance to pest and adverse environment. Further, the sustenance of response after sound exposure needs critical evaluation. For instance, strawberry plants showed growth promotion upon short sound exposure but longer exposure resulted in inhibition of growth.Different research groups touched upon epigenetic, transcriptional, hormonal and proteome level changes during specific sound treatment. However, multi-omics studies involving coding as well as non-coding regulatory RNA such as miRNA (microRNA), piRNA (piwi-interacting RNA), lncRNA (long non-coding RNA), epigenetic changes need to be conducted, without which holistic understanding of sound wave response is far from complete. Enhanced and time-lapse imaging of cells and subcellular compartments can reveal cellular changes upon sound exposures.Promoters are the DNA elements that are key to determining gene expression. Certain promoters are inducible in nature i.e., they lead to gene expression only upon being stimulated by an inducer. In a study, sound frequencies of 125 and 250 Hz were found to induce expression of two genes fructose 1,6-bisphosphate aldolase (ald) and Rubisco small sub-unit (rbcS) genes, which play critical roles in photosynthesis. Collins and Foreman used a specially designed environmental chambers with controlled growth conditions, coaxial speakers, measurements were taken from different positions of plants (impatiens and beans) . Growth was affected when plants were in direct path of sound. They reasoned that there must be a relationship between wavelength of sound and leaf dimension. The compression and rarefaction wave generated by speaker diaphragm movement makes the air on the leaf surface to move and helps the plant to breath more easily only when the wavelength of sound generated coincides with leaf dimension