What are the mechanisms by which cells sense and respond to oxidative stress, and how do these pathways impact aging?
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Cells utilize a variety of mechanisms to sense and respond to oxidative stress, including antioxidant defense systems, DNA repair pathways, and protein quality control processes. While these responses are crucial for maintaining cellular function, their efficiency declines with age, leading to the accumulation of oxidative damage. This contributes to the aging process and the development of age-related diseases. Understanding these pathways provides insights into potential therapeutic strategies to mitigate aging and promote healthy lifespan.