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Differentiate between mendelian and non-mendelian disorders
Mandalien disorders : ●It is a genetics disorder ●Chromosomes does not changes ●Only single gene is involved ●Cause mutation in single gene ●Also called as monotonic disorder ●Either dominant or recessive EX: 1.Haemophilia 2.sickle cell anemia 3.phenylketonuria 4.color blindness 5.thalassemia 6.cystRead more
Mandalien disorders :
●It is a genetics disorder
●Chromosomes does not changes
●Only single gene is involved
●Cause mutation in single gene
●Also called as monotonic disorder
●Either dominant or recessive
EX:
1.Haemophilia
2.sickle cell anemia
3.phenylketonuria
4.color blindness
5.thalassemia
6.cystic fibrosis
Non-mendelian disorder :
●It is a genetic disorder
●Cause error in cell division following meiosis and mitosis
●Chromosomes changes
●More than one gene is involved
●called as chromosomal disorder Neither dominant or recessive
EX:
1.Allosomal disorder
a.Klinefelter’s syndrome
b.Turner’s syndrome
2.Autosomal disorder
a .Down syndrome
b.Edwards syndrome
c.Patau syndrome
d.Cri-du-chat syndrome
See lessWhat are monoclonal antibodies, and how are they used in treating diseases?
monoclonal antibodies : All monoclonal antibodies are defending to the body against infection caused by microbes. This technique was discovered by MileStein and Kohler in 1975 and won Nobel prize in 1984 By using this hybridoma technique they created hybrid cell that will make a unlimited quantitiesRead more
monoclonal antibodies :Procedure:
Mice is injected with a antigen +adjuvant at primary dose.
Followed by second booster dose at the day of 14th and 28th day after that mice are incubated for 3 to 5 days then spleen cell is harvested and fused with plasma cell by fusing agent polyethylene glycol.
Unfused myleoma cell cannot grow because lack of enzyme HGPRT (hypoxanthine guanine phosphoribose transferase).
Unfused Spleen cell also cannot grow permanently due to their limited lifespan.
Spleen cell partner supplies HGPRT to myleoma cells whereas mylemoa cell gives life to spleen cell.
Thus process is exploited by transferring the hybrid call into medium is know as HAT(hypoxanthine Aminopterine Thymidine)
Antibodies are produced through this method which is used to treat many diseases.
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