CRISPER-CAS9 will be the future therapeutics to cure many genetic and non genetic disorders permanently without any side effects. Genetic disorders can be corrected through directing CAS9 protein towards the mutated sequence these help in deleting base mutations and treating the harmful mutation to new healthy DNA variety. Since the technology is entirely not know they show some of the bioethical and social concerns to alter the human genome, one of few is it is still not approved that the altered gene is transferred to the next generation and sometimes due to the cell repair mechanism they show uncertainty in the results. It also rises the social concern to altering the genome in the embryonic stage which is not accepted by the current society. But CRISPER-CAS9 therapy can achieve a greater height in immunotherapy.